ABSTRACT
Objetivo: El objetivo de este trabajo es demostrar la utilidad de las técnicas de tensor de difusión de alta densidad (DTI 32 direcciones) para visualizar el trayecto de los pares craneales antes de la cirugía en pacientes con patología tumoral de la base del cráneo. Materiales y métodos: Se estudiaron 26 pacientes con patología tumoral de la base del cráneo con secuencias de tensor de difusión de alta densidad. Los resultados imagenológicos fueron correlacionados con los hallazgos intraoperatorios. Resultados: En todos los pacientes estudiados fue posible la identificación prequirúrgica del recorrido de los nervios involucrados por las lesiones de la base del cráneo y también hubo una correlación entre los datos obtenidos mediante las imágenes y los hallazgos intraoperatorios. Conclusión: La visualización del recorrido de los nervios craneales mediante la difusión de alta densidad demostró ser segura y reproducible para identificar los pares y su recorrido...
Objective: The objective of this work is to demonstrate the usefulness of high density diffusion tensor imaging techniques (HD-DTI 32 directions), to visualize the course of the cranial nerves prior to surgery in patients with skull base tumor disease.Materials and methods: Twenty-six patients with skull base tumor disease were studied with sequences of high density diffusion tensor imaging. The imaging results were correlated with the intra-operative fi ndings.Results: Pre-surgical identifi cation of the course of the nerves affected by the injuries of the skull base was possible in all the studied patients, with the imaging results correlating with the intraoperative fi ndings.Conclusion: The visualization of the course of the cranial nerves with high density diffusion tensor imaging was shown to be safe and reproducible for the identifi cation of cranial nerves and their course...
Subject(s)
Humans , Male , Female , Cranial Nerves , Skull Base Neoplasms/complications , Skull Base Neoplasms , Diffusion Tensor Imaging , Magnetic Resonance ImagingABSTRACT
Osteoporosis in men was not recognized as a major health problem until recently, and increased research in this area resulted in the approval of alendronate for the treatment of osteoporosis in men at the beginning of this decade. Low bone mineral density (BMD) has been demonstrated to be a strong predictor of fracture in men as it is in women. The causes of osteoporosis in men are variable and can be classified as primary or secondary. The aim of these report is to present the response of BMD in 10 Puerto Rican men with secondary causes of osteoporosis treated with alendronate. A significant increase of BMD in spine, total hip, trochanter and intertrochanteric regions were noted. A non-significant increase in femoral neck was observed.
Subject(s)
Humans , Male , Adult , Middle Aged , Bone Density Conservation Agents/therapeutic use , Alendronate/therapeutic use , Bone Density/drug effects , Osteoporosis/drug therapy , Absorptiometry, Photon , Hispanic or Latino , Osteoporosis/diagnosis , Osteoporosis/ethnology , Puerto Rico/ethnology , Retrospective Studies , Treatment OutcomeABSTRACT
Se evaluó la actividad de ampicilina, ampicilina-sulbactama, cefoxitina, ceftriaxona, imipenem, piperacilina, piperacilina-tazobactama, clindamicina, metronidazol y azitromicina frente a 166 cepas de bacterias anaerobias aisladas en 8 hospitales de Buenos Aires. Se estudiaron: Bacteroides grupo fragilis (65), Fusobacterium spp. (26), Prevotella spp. (21), Porphyromonas spp. (10), Clostridium difficile (10), otros clostridios (12) y cocos gram-positivos (22). Las CIMs se determinaron usando el método patrón de dilución en agar recomendado por el NCCLS, documento M11-A5. Los antibióticos más activos fueron metronidazol y piperacilina-tazobactama que exhibieron valores de CIM90£ 2 µg/ml y £ 4 µg/ml frente a los microorganismos gram-negativos y £ 2 µg/ml y £ 8 µg/ml frente a los microorganismos gram-positivos, respectivamente. Entre los b-lactámicos el orden de actividad frente a bacilos gram-negativos fue: imipenem > piperacilina > cefoxitina > ceftriaxona > ampicilina. En gram-positivos la actividad decreciente fue: piperacilina> imipenem > cefoxitina > ceftriaxona > ampicilina. La mayoría de las especies estudiadas mostraron distintos niveles de resistencia con clindamicina y azitromicina. Sin embargo, el 90% de las cepas de Fusobacterium nucleatum y Por-phyromonas spp. fue inhibido por una concentración de 0,125 µg/ml de clindamicina y azitromicina, respectivamente.
The antimicrobial activity of ampicillin, ampicillin-sulbactam, cefoxitin, ceftriaxone, imipenem, piperacillin, piperacillin-tazobactam, clindamycin, metronidazole, and azitromycin was assesed against 166 strains of anaerobic bacteria recovered from eight hospitals in Buenos Aires. The strains studied were Bacteroidesfragilis group (65), Fusobacterium spp. (26), Prevotella spp. (21), Porphyromonas spp. (10), Clostridium difficile (10), other clostridia (12), and gram-positive cocci (22). The MICs were determined by the agar dilution method according to NCCLS document M11-A5. Metronidazole and piperacillin-tazobactam were the most active antimicrobial agents tested and exhibited MIC90values of £ 2 µg/ml and £ 4 µg/ml against gram-negative organisms, and £ 2 µg/ml, and £ 8 µg/ml against gram-positive organisms, respectively. Among b-lactams the activity against gram-negative rods was in the following order: imipenem> piperacillin > cefoxitin > ceftriaxone > ampicillin. Among the gram-positive bacteria the decreased activity was: piperacillin> imipenem> cefoxitin > ceftriaxone > ampicillin. The majority of the species studied showed different degrees of resistance to clindamycin and azitromycin. Nevertheless, 90% of Fusobacterium nucleatum and Porphyromonas spp. isolates were inhibited by 0.125 mg/ml of clindamycin and azitromycin, respectively.
Subject(s)
Humans , Anti-Bacterial Agents/pharmacology , Bacteria, Anaerobic/drug effects , Drug Resistance, Bacterial , In Vitro Techniques , Argentina , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/classification , Bacteria, Anaerobic/isolation & purification , Bacterial Infections/microbiology , Cross Infection/microbiology , Dose-Response Relationship, Drug , Drug Resistance, Multiple, Bacterial , Gram-Negative Anaerobic Bacteria/drug effects , Gram-Negative Anaerobic Bacteria/isolation & purification , Gram-Positive Bacteria/drug effects , Gram-Positive Bacteria/isolation & purification , Microbial Sensitivity Tests , Species SpecificityABSTRACT
The antimicrobial activity of ampicillin, ampicillin-sulbactam, cefoxitin, ceftriaxone, imipenem, piperacillin, piperacillin-tazobactam, clindamycin, metronidazole, and azitromycin was assesed against 166 strains of anaerobic bacteria recovered from eight hospitals in Buenos Aires. The strains studied were Bacteroides fragilis group (65), Fusobacterium spp. (26), Prevotella spp. (21), Porphyromonas spp. (10), Clostridium difficile (10), other clostridia (12), and gram-positive cocci (22). The MICs were determined by the agar dilution method according to NCCLS document M11-A5. Metronidazole and piperacillin-tazobactam were the most active antimicrobial agents tested and exhibited MIC90 values of piperacillin > cefoxitin > ceftriaxone > ampicillin. Among the gram-positive bacteria the decreased activity was: piperacillin > imipenem > cefoxitin > ceftriaxone > ampicillin. The majority of the species studied showed different degrees of resistance to clindamycin and azitromycin. Nevertheless, 90
of Fusobacterium nucleatum and Porphyromonas spp. isolates were inhibited by 0.125 mg/ml of clindamycin and azitromycin, respectively.
ABSTRACT
Hereditary (HAE) and acquired (AAE) angioedema are vascular reactions involving the sub mucosal tissues, representing localized edema caused by dilatation and increased permeability of the capillaries. HAE and AAE are clinical disorders characterized by angioedema that require prompt differentiation from other causes of angioedema in order to receive the most pertinent and effective therapeutic interventions. The aim of this report is to describe the clinical characteristics of patients with both HAE and AAE identified and followed at the Immunology Clinic of the University Hospital at the Puerto Rico Medical Center, their response and side effects to danazol therapy and their comparison with other series of similar patients reported in the literature. Overall, the patients in this sample presented a similar clinical profile compared to other reported series in the literature.
Subject(s)
Humans , Male , Female , Child , Adolescent , Adult , Middle Aged , Angioedema , Estrogen Antagonists/administration & dosage , Estrogen Antagonists/adverse effects , Estrogen Antagonists/therapeutic use , Complement C1 , Complement C1q , Complement C4 , Data Interpretation, Statistical , Diagnosis, Differential , Danazol/administration & dosage , Danazol/adverse effects , Danazol/therapeutic use , Enzyme-Linked Immunosorbent Assay , Immunodiffusion , Complement Inactivating Agents/analysis , Time FactorsABSTRACT
El objetivo de este trabajo de investigación es demostrar la importancia de la detección temprana de hipoacusias en recién nacidos, para evitar posteriores alteraciones linguisticas, sociales y cognitivas en los niños, realizando para tal fin screening universal y búsqueda activa de alteraciones auditivas en neonatos. Se aplicaron métodos subjetivos como también electrofisiológicos, con una prevalencia de hipoacusia neurosensorial bilateral severa o profunda del 2,5 al 3 por ciento. Los resultados obtenidos demostraron que si bien existen diferencias de opinión considerables en relación a especificidad y sensibilidad de las téncias disponibles, un examen subjetivo aplicado en el momento exacto y por profesionales capacitados nos ofrece también alto grado de especificidad y sensibilidad como primer método de rastreo
Subject(s)
Humans , Male , Female , Infant, Newborn , Hearing Disorders/diagnosis , Sensitivity and Specificity , Neonatal Screening , Hearing Loss, Sensorineural/epidemiology , Diagnostic Techniques, OtologicalSubject(s)
Humans , Female , Adult , Breast Neoplasms , Lymphatic Irradiation/methods , Mammography/statistics & numerical dataSubject(s)
Infant , Dogs , Bites and Stings/complications , Brain Abscess/etiology , Propionibacterium acnes/pathogenicity , Bites and Stings/microbiology , Brain Abscess/drug therapy , Brain Abscess/microbiology , Dogs , Pasteurella multocida/pathogenicity , Propionibacterium acnes/isolation & purificationABSTRACT
Se determinó la actividad de ampicilina (AMP), ampicilina-sulbactama (AMS), penicilina (PEN), piperacilina (PIP), imipenem (IMI), cefoxitina (CXT), ceftizoxima (CFZ), clindamicina (CLI), cloranfenicol (CLO) y metronidazol (MET) frente a 106 cepas de bacterias anaerobias aisladas de muestras clínicas en seis centros asistenciales del país por un método de dilución en agar. Todos los microorganismos gramnegativos fueron sensibles a AMS, CLO, IMI y MET. Se encontraron 5/7 Bacteroides spp., 2/6 bacilos gram negativos pigmentados y 1/4 Fusobacterium spp. resistentes a AMP. Los Bacteroides del grupo fragilis fueron altamente resistentes a AMP y la especie Bacteroides fragilis fue más sensible a PIP, CXT, CFZ y CLI que las otras especies del grupo (5 por ciento vs. 21 por ciento, 5 por ciento vs. 7 por ciento, 8 por ciento vs. 14 por ciento y 2,5 por ciento vs. 14 por ciento respectivamente). Entre los organismos gram positivos se encontró resistencia PEN en el 7 por ciento de Peptostreptococcus spp., a MET en 4 de 5 bacilos no esporulados y sensibilidad al resto de los antibióticos